I want to come to the UK on Tier 1 VISA. I work in a MNC at Bangalore, I've Masters Degree and earn good salary. Can I qualify for the Tier 1? Do I need work in order to apply qualify for Tier 1 VISA?

It is too tough now a days to qualify for the Tier 1. They have already cut the quota for skilled immigrants from non EU countries and soon they will scrap it all together. You can check on Home Office's website for the points you can get.

UK Border Agency | Points-based calculator